Online Hemodiafiltration Reduces Bisphenol A Levels
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- 作者：Borja Quiroga ; Ricardo J. Bosch ; Ruth A. Fiallos ; Marta Sá ; nchez-Heras ; Nuria Olea-Herrero ; Pilar Ló ; pez-Aparicio ; Carmen Muñ ; ó ; z-Moreno ; Miguel Angel Pé ; rez-Alvarsan and Gabriel De Arriba
- 刊名：Therapeutic Apheresis and Dialysis
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：21
- 期：1
- 页码：96-101
- 全文大小：179K
- ISSN：1744-9987
文摘
Several uremic toxins have been identified and related to higher rates of morbidity and mortality in dialysis patients. Bisphenol A (BPA) accumulates in patients with chronic kidney disease. The aim of this study is to demonstrate the usefulness of online hemodiafiltration (OL-HDF) in reducing BPA levels. Thirty stable hemodialysis patients were selected to participate in this paired study. During three periods of 3 weeks each, patients were switched from high-flux hemodialysis (HF-HD) to OL-HDF, and back to HF-HD. BPA levels were measured in the last session of each period (pre- and post-dialysis) using ELISA and HPLC. Twenty-two patients (mean age 73 ± 14 years; 86.4% males) were included. Measurements of BPA levels by HPLC and ELISA assays showed a weak but significant correlation (r = 0.218, P = 0.012). BPA levels decreased in the OL-HDF period of hemodialysis, in contrast to the HF-HD period when they remained stable (P = 0.002). In conclusion, OL-HDF reduced BPA levels in dialysis patients.