Invited for the cover of this issue is the group of Karl Anker J&
oslash;rgensen at Aarhus University. The image depicts the basic reaction concept of the asymmetric catalytic aza-Diels–Alder/ring-closing cascade by the operation mode of a zipper. The two molecules (red 2,4-dienal; blue hydrazone) in this reaction are mosaicked into the two chains of the zipper. The chiral slider, the diarylprolinol-silyl ether catalyst, zips together the two molecules by sliding the hand down the chains forming the bicyclic aza-heterocyclic products in a highly stereoselective manner. Read the full text of the article at
10.1002/chem.201604310.