UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal Extracts

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• 作者：Vincent Zwick ; Pierre-Marie Allard ; Lucie Ory ; Claudia A. Sim&otilde ; es-Pires ; Laurence Marcourt ; Katia Gindro ; Jean-Luc Wolfender and Muriel Cuendet
• 刊名：Phytochemical Analysis
• 出版年：2017
• 出版时间：March/April 2017
• 年：2017
• 卷：28
• 期：2
• 页码：93-100
• 全文大小：285K
• ISSN：1099-1565

文摘

Histone deacetylases (HDAC) are considered as promising targets for cancer treatment. Today, four HDAC inhibitors, vorinostat, romidepsin, belinostat, and panobinostat, have been approved by the Food and Drug Administration (FDA) for cancer treatment, while others are in clinical trials. Among them, several are naturally occurring fungal metabolites.