Synthesis of Pyrimido[5′,4′:4,5]pyrrolo[1,2-f]phenanthridines by a One-Pot C-N-Coupling/Hydroamination/C-H-Arylation Sequence
详细信息 查看全文
- 作者：Ngo Nghia Pham ; Ghazwan Ali Salman ; Nadjah Belattar ; Tuan Thanh Dang ; Peter Ehlers and Peter Langer
- 刊名：European Journal of Organic Chemistry
- 出版年：2017
- 出版时间：February 03, 2017
- 年：2017
- 卷：2017
- 期：5
- 页码：989-995
- 全文大小：917K
- ISSN：1099-0690
文摘
A modular and atom-economic synthetic pathway towards 11,13-dimethylpyrimido[5′,4′:4,5]pyrrolo[1,2-f]phenanthridines is described. The protocol features a chemoselective Sonogashira reaction of a 4,5-dihalopyrimidine followed by a domino C–N coupling/hydroamination and C–H arylation that can be achieved in a one-pot process. The yields vary from moderate to good.