The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4′-hydroxystilbene and trans-2,4′,5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans
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- 作者：Nadine Fischer ; Christian Bü ; chter ; Karoline Koch ; Sabrina Albert ; René ; Csuk and Wim Wä ; tjen
- 刊名：Journal of Pharmacy and Pharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：69
- 期：1
- 页码：73-81
- 全文大小：751K
- ISSN：2042-7158
文摘
Resveratrol (trans-3,4′,5-trihydroxystilbene (1)) was previously shown to extend the lifespan of different model organisms. However, its pharmacological efficiency is controversially discussed. Therefore, the bioactivity of four newly synthesized stilbenes (trans-3,5-dimethoxy-4-fluoro-4′-hydroxystilbene (3), trans-4′-hydroxy-3,4,5-trifluorostilbene (4), trans-2,5-dimethoxy-4′-hydroxystilbene (5), trans-2,4′,5-trihydroxystilbene (6)) was compared to (1) and pterostilbene (trans-3,5-dimethoxy-4′-hydroxystilbene (2)) in the established model organism Caenorhabditis elegans.