Synthesis and Evaluation of Novel 5-cyclohexyl-2-(4″-substitutedphenyl)-3-(2″-substitutedphenyl)4H-2,3,3a,5,6,6a-hexahydropyrrolo[3,4-d]isoxazole-4,6-dione Derivatives for Their In Vitro Antioxidant and Antibacterial Activities

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• 作者：Manpreet Kaur ; Anjandeep Kaur ; Baldev Singh and Baljit Singh
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：80-88
• 全文大小：307K
• ISSN：1943-5193

文摘

4">1,3-Dipolar cycloaddition reactions of 43-eo-0001">N-cyclohexyl maleimide (43-eo-0001" rel="references:#jhet2543-eo-0001">) with azomethine N-oxide (43-eo-0002" rel="references:#jhet2543-eo-0002">) have afforded novel isoxazolidine (43-eo-0003" rel="references:#jhet2543-eo-0003">) in excellent yield. Their structures have been characterized from their IR, ¹H-NMR, ¹³C-NMR, ¹H,¹H-COSY, MS(ESI), and elemental analysis techniques. In vitro antibacterial activity of the synthesized compounds were investigated against a representative panel of pathogenic strains specifically two Gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes) and two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli) using agar-well diffusion assay. Some of the compounds (43-eo-0004" rel="references:#jhet2543-eo-0004">, 43-eo-0014" rel="references:#jhet2543-eo-0014">, 43-eo-0017" rel="references:#jhet2543-eo-0017">, and 43-eo-0018" rel="references:#jhet2543-eo-0018">) exhibited promising antibacterial activities. All the synthesized compounds have also been screened for their antioxidant activities and were found to be significantly active.