Electrochemical C−H/N−H Functionalization for the Synthesis of Highly Functionalized (Aza)indoles

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• 作者：Zhong-Wei Hou ; Zhong-Yi Mao ; Huai-Bo Zhao ; Yared Yohannes Melcamu ; Prof. Dr. Xin Lu ; Dr. Jinshuai Song and Prof. Dr. Hai-Chao Xu
• 刊名：Angewandte Chemie
• 出版年：2016
• 出版时间：August 1, 2016
• 年：2016
• 卷：128
• 期：32
• 页码：9314-9318
• 全文大小：3451K
• ISSN：1521-3757

文摘

Indoles and azaindoles are among the most important heterocycles because of their prevalence in nature and their broad utility in pharmaceutical industry. Reported herein is an unprecedented noble-metal- and oxidant-free electrochemical method for the coupling of (hetero)arylamines with tethered alkynes to synthesize highly functionalized indoles, as well as the more challenging azaindoles.