First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols

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• 作者：Giuseppe Rulli ; Nongnaphat Duangdee ; Werner Hummel ; Albrecht Berkessel and Harald Grö ; ger
• 刊名：European Journal of Organic Chemistry
• 出版年：2017
• 出版时间：January 26, 2017
• 年：2017
• 卷：2017
• 期：4
• 页码：812-817
• 全文大小：1228K
• ISSN：1099-0690

文摘

A suitable “process window” was identified for the combination of an asymmetric organocatalytic aldol reaction and subsequent biocatalytic reduction in aqueous medium, which thus enabled the enantio- and diastereoselective synthesis of 1,3-diols in a tandem-type, one-pot process. A key feature of this one-pot synthesis is the high 500 mm loading of the aldehyde substrate used as a starting material.