Synthesis of 2-(methylsulfonyl)-5-(4-(methylsulfonyl) phenyl)-4-phenyl-1H-[5-14C]imidazole, a selective COX-2 inhibitor, via asymmetrical benzoins

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• 作者：Gholamhossein Shirvani ; Abbas Shockravi ; Mohsen Amini and Nader Saemian
• 关键词：4 ; 5-diarylimidazole ; asymmetrical benzoins ; selective COX-2 inhibitors ; carbon-14
• 刊名：Journal of Labelled Compounds and Radiopharmaceuticals
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：59
• 期：4
• 页码：153-156
• 全文大小：378K
• ISSN：1099-1344

文摘

4,5-Diarylimidazoles labeled with carbon-14 in the 5-position of the imidazole ring were prepared as a part of three-step sequence from 2-hydroxy-1-(4-(methylthio)phenyl)-2-phenyl[1-¹⁴C]ethanone as a key synthetic intermediate which has been synthesized from potassium [¹⁴C]cyanide.