ChemInform Abstract: An Enantioselective Three-Component Reaction of Diazoacetates with Indoles and Enals by Iridium/Iminium Co-Catalysis.
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- 作者：Mingfeng Li ; Xin Guo ; Weifeng Jin ; Qing Zheng ; Shunying Liu and Wenhao Hu
- 关键词：indole derivatives ; isoindole derivatives ; C-C bond formation ; catalysis ; phase-transfer catalysis ; diastereoselective syntheses ; enantioselective syntheses (incl. cis/trans-isomerism) ; multicomponent reactions ; Editors' Choice
- 刊名：ChemInform
- 出版年：2016
- 出版时间：April, 2016
- 年：2016
- 卷：47
- 期：19
- 全文大小：30K
- ISSN：1522-2667
文摘
The first example of chiral secondary amine and iridium(I) co-catalyzed enantioselective three-component reaction of aryldiazoacetates, indoles and enals is developed to afford 3-substituted indole derivatives in good yields and with moderate diastereoselectivity as well as excellent enantioselectivity.