Benzodifuran Derivatives as Potential Antiproliferative Agents: Possible Correlation between Their Bioactivity and Aggregation Properties

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• 作者：Dr. Domenica Musumeci ; Dr. Giovanni N. Roviello ; Dr. Giuseppina Rigione ; Dr. Domenica Capasso ; Dr. Sonia Di Gaetano ; Dr. Claudia Riccardi ; Valentina Roviello and Prof. Daniela Montesarchio
• 刊名：ChemPlusChem
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：82
• 期：2
• 页码：251-260
• 全文大小：1838K
• ISSN：2192-6506

文摘

To further explore the properties and bioactivity of benzodifurans, three compounds in this class were synthesised and characterised using spectroscopic and spectrometric techniques, as well as SEM and thermogravimetric analysis. The synthesised compounds showed interesting antiproliferative activity on different human cancer cells (HeLa, Hep-G2, WM266), whereas no relevant cytotoxic effect was observed on healthy control cells. To study the possible mechanism of action of the benzodifurans, their ability to bind various model DNA systems, their aggregation properties, and their ability to bind biologically relevant metal ions was evaluated. The molecules were found to form monodisperse nanoaggregates stable at physiological temperature, which are likely related to the observed bioactivity.