Development of an in vivo model of laryngeal burn injury

详细信息    查看全文

• 作者：Gregory R. Dion ; Stephanie Teng ; Renjie Bing ; Nao Hiwatashi ; Milan R. Amin and Ryan C. Branski
• 刊名：The Laryngoscope
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：127
• 期：1
• 页码：186-190
• 全文大小：423K
• ISSN：1531-4995

文摘

Inhalation injury significantly increases morbidity and mortality in burn patients. Approximately one in five burn patients have acute injury to the larynx, trachea, and/or lungs—and as many as 70% have long-term laryngeal abnormalities. Although inhalation injury to the lung has been studied extensively, no models exist to study these insults to the larynx. As such, we developed an in vivo rabbit model to create precise and reproducible laryngeal burn with resultant tissue damage as a foundation for interventional studies.