Facile Preparation of Multifunctional WS₂/WO_x Nanodots for Chelator-Free ⁸⁹Zr-Labeling and In Vivo PET Imaging

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• 作者：Liang Cheng ; Anyanee Kamkaew ; Sida Shen ; Hector F. Valdovinos ; Haiyan Sun ; Reinier Hernandez ; Shreya Goel ; Teng Liu ; Cyrus R. Thompson ; Todd E. Barnhart ; Zhuang Liu and Weibo Cai
• 刊名：Small
• 出版年：2016
• 出版时间：November 2, 2016
• 年：2016
• 卷：12
• 期：41
• 页码：5750-5758
• 全文大小：1891K
• ISSN：1613-6829

文摘

While position emission tomography (PET) is an important molecular imaging technique for both preclinical research and clinical disease diagnosis/prognosis, chelator-free radiolabeling has emerged as a promising alternative approach to label biomolecules or nanoprobes in a facile way. Herein, starting from bottom-up synthesized WS₂ nanoflakes, this study fabricates a unique type of WS₂/WO_x nanodots, which can function as inherent hard oxygen donor for stable radiolabeling with Zirconium-89 isotope (⁸⁹Zr). Upon simply mixing, ⁸⁹Zr can be anchored on the surface of polyethylene glycol (PEG) modified WS₂/WO_x (WS₂/WO_x-PEG) nanodots via a chelator-free method with surprisingly high labeling yield and great stability. A higher degree of oxidation in the WS₂/WO_x-PEG sample (WS₂/WO_x (0.4)) produces more electron pairs, which would be beneficial for chelator-free labeling of ⁸⁹Zr with higher yields, suggesting the importance of surface chemistry and particle composition to the efficiency of chelator-free radiolabeling. Such ⁸⁹Zr-WS₂/WO_x (0.4)-PEG nanodots are found to be an excellent PET contrast agent for in vivo imaging of tumors upon intravenous administration, or mapping of draining lymph nodes after local injection.