Reduced microRNA-188-3p expression contributes to apoptosis of spermatogenic cells in patients with azoospermia

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• 作者：Wen-Yan Song ; Hui Meng ; Xue-Gai Wang ; Hai-Xia Jin ; Gui-Dong Yao ; Sen-Lin Shi ; Liang Wu ; Xiang-Yang Zhang and Ying-Pu Sun
• 刊名：Cell Proliferation
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：50
• 期：1
• 全文大小：803K
• ISSN：1365-2184

文摘

Human mutL homologl (MLH1) works coordinately in sequential steps to initiate repair of DNA mismatches, and aberrant MLH1 expression is related to spermatogenetic malfunction. In the present study, MLH1 expression in patients with azoospermia was investigated, and moderating effects of miR-188-3p on MLH1 expression and spermatogenesis were identified.