An Amphiphilic Ruthenium Polymetallodrug for Combined Photodynamic Therapy and Photochemotherapy In Vivo
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- 作者：Wen Sun ; Shuyi Li ; Bernhard Hä ; upler ; Juan Liu ; Shubin Jin ; Werner Steffen ; Ulrich S. Schubert ; Hans-Jü ; rgen Butt ; Xing-Jie Liang and Si Wu
- 刊名：Advanced Materials
- 出版年：2017
- 出版时间：February 10, 2017
- 年：2017
- 卷：29
- 期：6
- 全文大小：2231K
- ISSN：1521-4095
文摘
An amphiphilic Ru-containing block copolymer is used as a photoactivated polymetallodrug for anticancer phototherapy. The block copolymer self-assembles into nanoparticles, which can accumulate at tumor sites in a mouse model. Red light irradiation of the block copolymer nanoparticles releases anticancer Ru complexes and generates cytotoxic 1O2, both of which can inhibit tumor growth.