Selection biases in observational studies affect associations between ‘moderate’ alcohol consumption and mortality
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- 作者：Timothy S. Naimi ; Timothy Stockwell ; Jinhui Zhao ; Ziming Xuan ; Frida Dangardt ; Rich Saitz ; Wenbin Liang and Tanya Chikritzhs
- 刊名：Addiction
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：112
- 期：2
- 页码：207-214
- 全文大小：267K
- ISSN：1360-0443
文摘
Selection biases may lead to systematic overestimate of protective effects from ‘moderate’ alcohol consumption. Overall, most sources of selection bias favor low-volume drinkers in relation to non-drinkers. Studies that attempt to address these types of bias generally find attenuated or non-significant relationships between low-volume alcohol consumption and cardiovascular disease, which is the major source of possible protective effects on mortality from low-volume consumption. Furthermore, observed mortality effects among established low-volume consumers are of limited relevance to health-related decisions about whether to initiate consumption or to continue drinking purposefully into old age. Short of randomized trials with mortality end-points, there are a number of approaches that can minimize selection bias involving low-volume alcohol consumption.