ChemInform Abstract: Recyclable Organocatalyst-Promoted One-Pot Asymmetric Synthesis of Spirooxindoles Bearing Multiple Stereogenic Centers.
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- 作者：Xin Huang ; Kenny Pham ; Wenbin Yi ; Xiaofeng Zhang ; Cecilia Clamens ; Jeremy H. Hyatt ; Jerry P. Jasinsk ; Uriel Tayvah and Wei Zhang
- 关键词：spirocyclic compounds (heterocyclic compounds) ; indole derivatives ; isoindole derivatives ; pyridine derivatives ; multicomponent reactions ; ring closure reactions ; annulation reactions ; organocatalysis ; diastereoselective syntheses ; enantioselective syntheses (incl. cis/trans-isomerism)
- 刊名：ChemInform
- 出版年：2016
- 出版时间：April, 2016
- 年：2016
- 卷：47
- 期：18
- 全文大小：30K
- ISSN：1522-2667
文摘
A recyclable fluorous bifunctional Cinchona alkaloid/thiourea-catalyzed, one-pot four-component Michael/Mannich/cyclization sequence is developed for the asymmetric synthesis of spirooxindoles containing 2-piperidinone and tetrahydropyridine rings.