Optimization of a novel chelerythrine-loaded magnetic Fe3O4/chitosan alpha-ketoglutaric acid system and evaluation of its anti-tumour activities

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• 作者：Fei Yang ; Wen Xiao ; Xiaohua Ma ; Ruixue Huang ; Ran Yu ; Guiyin Li ; Xiao Huang ; Cuimei Chen and Ping Ding
• 刊名：Journal of Pharmacy and Pharmacology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：68
• 期：8
• 页码：1030-1040
• 全文大小：924K
• ISSN：2042-7158

文摘

A novel magnetic targeting anti-tumour drug delivery system (Fe₃O₄/KCTS-CHE) was designed using magnetic Fe₃O₄/chitosan alpha-ketoglutaric acid (Fe₃O₄/KCTS) as carrier and chelerythrine (CHE) as an anti-tumour drug model. Moreover, the anti-tumour activities and mechanisms of Fe₃O₄/KCTS-CHE were investigated.