Association of EPHB1 rs11918092 and EFNB2 rs9520087 with psychopathological symptoms of schizophrenia in Chinese Zhuang and Han populations

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• 作者：Li Su ; Weijun Ling ; Juan Jiang ; Jing Hu ; Jingyuan Fan ; Xiaojing Guo ; Guifeng Huang ; Xinfeng Xie and Jianxiong Long
• 刊名：Asia-Pacific Psychiatry
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：8
• 期：4
• 页码：306-308
• 全文大小：226K
• ISSN：1758-5872

文摘

Two single-nucleotide polymorphisms (SNPs) (rs11918092 and rs9520087) were genotyped in Chinese Zhuang and Han populations. Symptoms of schizophrenic patients were assessed by the Positive and Negative Syndrome Scale. No association of any SNP with schizophrenic susceptibility was found. However, associations of rs9520087 with the total scale score (P = 0.014), positive scale score (P = 0.013), negative scale score (P = 0.032), and general psychopathology scale score (P = 0.031) were found in Zhuang patients. Additionally, rs11918092 was associated with positive scale score (P = 0.035) in Han patients. The two SNPs might influence symptoms of schizophrenia.