ChemInform Abstract: A Cascade Reaction of O-Alkenylphenyl Carbodiimides with Isocyanides by Copper Catalysis: Direct Construction of 4,5-Dihydroimidazo[1,5-a]quinazolines.
The Cu-catalyzed reaction of ortho-alkenyl substituted phenyl carbodiimides (I) with isocyanoacetate (II) initially proceeds through a [3 + 2] cycloaddition followed by an intramolecular conjugate addition annulation to give the title compounds (III) in moderate to good yields.