915 nm Light-Triggered Photodynamic Therapy and MR/CT Dual-Modal Imaging of Tumor Based on the Nonstoichiometric Na0.52YbF3.52:Er Upconversion Nanoprobes

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• 作者：Yanan Huang ; Qingbo Xiao ; Huishan Hu ; Kunchi Zhang ; Yamin Feng ; Fujin Li ; Jian Wang ; Xianguang Ding ; Jiang Jiang ; Yanfang Li ; Liyi Shi and Hongzhen Lin
• 刊名：Small
• 出版年：2016
• 出版时间：August 17, 2016
• 年：2016
• 卷：12
• 期：31
• 页码：4200-4210
• 全文大小：1476K
• ISSN：1613-6829

文摘

Lanthanide (Ln³⁺)-doped upconversion nanoparticles (UCNPs) as a new generation of multimodal bioprobes have attracted great interest for theranostic purpose. Herein, red emitting nonstoichiometric Na_0.52YbF_3.52:Er UCNPs of high luminescence intensity and color purity are synthesized via a facile solvothermal method. The red UC emission from the present nanophosphors is three times more intense than the well-known green emission from the ≈30 nm sized hexagonal-phase NaYF₄:Yb,Er UCNPs. By utilizing Na_0.52YbF_3.52:Er@SrF₂ UCNPs as multifunctional nanoplatforms, highly efficient in vitro and in vivo 915 nm light-triggered photodynamic therapies are realized for the first time, with dramatically diminished overheating yet similar therapeutic effects in comparison to those triggered by 980 nm light. Moreover, by virtue of the high transverse relaxivity (r ₂) and the strong X-ray attenuation ability of Yb³⁺ ions, these UCNPs also demonstrate good performances as contrast agents for high contrast magnetic resonance and X-ray computed tomography dual-modal imaging. Our research shows the great potential of the red emitting Na_0.52YbF_3.52:Er UCNPs for multimodal imaging-guided photodynamic therapy of tumors.