Efficient tumor eradication by endogenous synergistic cancer t
herapy has been developed by combining NO gas t
herapy with starvation of tumor cells. In t
heir Communication on
page 1229 ff., P. Huang, T. Wang, X. C
hen et al. describe a biocompatible porous nanocap
sule formula made of an organosilicate that transports glucose oxidase and
l-arginine into tumor cells simultaneously. This glucose-responsive nanomedicine shows sequential generation of H<
sub>2
sub>O<
sub>2
sub> and NO.