Divergent Aerobic Oxidative Ring-Opening Cascades of Isatins with 1,2,3,4-Tetrahydroisoquinoline
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- 作者：Peng-Ju Xia ; Jun-An Xiao ; Yan-Hua Sun ; Jun Li ; Hao-Yue Xiang ; Xiao-Qing Chen and Hua Yang
- 刊名：European Journal of Organic Chemistry
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：2016
- 期：30
- 页码：5096-5101
- 全文大小：1610K
- ISSN：1099-0690
文摘
The unprecedented aerobic oxidative ring-opening-initiated cascades of isatins with 1,2,3,4-tetrahydroisoquinoline were explored, in which the reaction sequence could be readily modulated by simply introducing a protecting group in the isatin. Consequently, quinazoline-2,4-diones and polycyclic 2,3-dihydro-4(1H)-quinazolinones with potential bioactivities were efficiently assembled in moderate chemical yields.