Black Phosphorus: Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics (Adv. Mater. 1/2017)

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• 作者：Wei Tao ; Xianbing Zhu ; Xinghua Yu ; Xiaowei Zeng ; Quanlan Xiao ; Xudong Zhang ; Xiaoyuan Ji ; Xusheng Wang ; Jinjun Shi ; Han Zhang and Lin Mei
• 刊名：Advanced Materials
• 出版年：2017
• 出版时间：January 4, 2017
• 年：2017
• 卷：29
• 期：1
• 全文大小：2176K
• ISSN：1521-4095

文摘

In article 1603276, J. Shi, H. Zhang, L. Mei, and co-workers describe black phosphorus nanosheets (BP NSs), which could lead to an enhanced antitumor effect, by a triple-response combined therapy strategy. When they enter the cancer cell, the BP NSs can produce a local high temperature initiated by an 808 nm laser. Release of loaded doxorubicin can be triggered by the laser and heat, leading to a combined photothermal–chemotherapy effect, which effectively kills the cancer cell. Moreover, under the influence of chloroquine, the degradation of BP NSs in the lysosome can be inhibited. The drug is then concentrated in the cell nucleus.