Electrochemical DNA biosensor based on poly(2,6-pyridinedicarboxylic acid) modified glassy carbon electrode for the determination of anticancer drug gemcitabine
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- 作者：Gö ; zde Aydoğdu Tığa ; gaydogdu@science.ankara.edu.tr" class="auth_mail" title="E-mail the corresponding author ; Bü ; lent Zeybekb ; Şule Pekyardımcıa
- 关键词：Gemcitabine ; dsDNA ; Glassy carbon electrode ; Polymer ; Differential pulse voltammetry
- 刊名：Talanta
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：154
- 期：Complete
- 页码：312-321
- 全文大小：1794 K
文摘
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Poly(2,6-pyridinedicarboxlic acid) (P(PDCA)) was coated on a glassy carbon electrode.
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The biosensor was fabricated by immobilization of dsDNA on P(PDCA) modified electrode.
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The determination of gemcitabine (GEM) was performed by using this electrode.
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The dsDNA biosensor presented a linear response range from 1.0 to 30 mg L−1 for GEM.
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GEM and dsDNA interaction was investigated via DPV and UV-vis spectroscopy.