Role of crystallins in diabetic complications
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- 作者：Vadde Sudhakar Reddy ; G. Bhanuprakash Reddy ; geereddy@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; bhanu@ninindia.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：αAC ; alphaA-crystallin ; αBC ; alphaB-crystallin ; STZ ; streptozotocin ; OLETF ; Otsuka Long-Evans Tokushima Fatty ; AGE ; advanced glycation end products ; MGO ; methylglyoxal ; RPE ; retinal pigment epithelium ; TOM 20 ; translocase of outer mitochondrial membrane 20 ; kDa ; VDAC ; voltage-dependent anion channel
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1860
- 期：1
- 页码：269-277
- 全文大小：1134 K
文摘
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Upregulation of crystallins is a common feature of chronic diabetic complications.
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Chronic hyperglycemia alters the structure and function of crystallins by glycation and phosphorylation.
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Glycation and phosphorylation modulate the apoptotic and other functions of crystallins.
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Altered interaction of αBC and mediators of apoptosis is responsible for increased cell death chronic diabetic complications.