Structure-activity relationships of ω-Agatoxin IVA in lipid membranes

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• 作者：Jae Ha Ryu^a ; Hoi Jong Jung^a ; Shiro Konishi^b ; Ha Hyung Kim^c ; Zee-Yong Park^a ; ^{zeeyong@gist.ac.kr} ; Jae Il Kim^a ; ^{jikim@gist.ac.kr}
• 关键词：ω-Agatoxin IVA ; Gating modifier toxin ; Cav2.1
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：482
• 期：1
• 页码：170-175
• 全文大小：1437 K
• 卷排序：482

文摘

The NMR structure of ω-Aga IVA in DPC micelles is determined. ω-Aga IVA stabilized its C-terminal tail with a β-turn structure within micelles. Both the C-terminal tail and Arg patch play a crucial role for blocking Cav2.1.