Discovery of a novel fluorescent probe for the sensitive detection of 尾-amyloid deposits
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- 作者：Wenming Renb ; 1 ; Mingming Xuc ; 1 ; Steven H. Liangd ; Huaijiang Xianga ; Li Tanga ; Minkui Zhanga ; Dejun Dingb ; Xin Lia ; lixin81@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Haiyan Zhangc ; hzhang@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Youhong Hua ; b ; yhhu@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fluorescent probe ; Imaging ; A尾 plaques ; Alzheimer's disease ; Photoinduced electron transfer
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：136-141
- 全文大小：2168 K
文摘
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A probe for no washing staining of A尾 plaques is developed.
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The probe can bind A尾 aggregates with high affinity.
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Binding to A尾 plaques will trigger dramatic fluorescence enhancement.
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Sensitive and no-wash staining of A尾 plaques in brain tissues is realized.