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• 作者：Li ; Jianyong ; Beerntsen ; Brenda T. ; James ; Anthony A.
• 关键词：Aedes aegypti ; 3-hydroxykynurenine ; Xanthommatin ; Ommochrome ; Eye pigment ; Transaminase ; Xanthurenic acid ; Phenoxazinone synthase
• 刊名：Insect Biochemistry and Molecular Biology
• 出版年：1999
• 出版时间：April, 1999
• 年：1999
• 卷：29
• 期：4
• 页码：329-338
• 全文大小：253 K

文摘

This study concerns the metabolic pathways of 3-hydroxykynurenine in Aedes aegypti mosquitoes during development with emphasis on its oxidation pathway to produce xanthommatin during eye pigmentation. Oxidation of tryptophan to 3-hydroxykynurenine is the major pathway of tryptophan catabolism in Aedes aegypti, but 3-hydroxykynurenine oxidizes easily under physiological conditions, which stimulate the production of reactive oxygen species. Our data show that in Aedes aegypti, the chemically reactive 3-hydroxykynurenine is converted to the chemically stable xanthurenic acid by a transaminase-catalyzed reaction during larval development, while 3-hydroxykynurenine is transported to the compound eyes for eye pigmentation during pupal development. Our data suggest that (1) the transamination pathway of 3-hydroxykynurenine is down-regulated during the pupal development, (2) 3-hydroxykynurenine produced in other body tissues is actively transported to the compound eyes during the pupal stage, (3) the compound eye is the place where ommochromes are produced, and (4) formation of ommochromes results from nonenzymatic oxidation of 3-hydroxykynurenine in the compound eyes. Publisher: Elsevier Science Language of Publication: English Item Identifier: S0965-1748(99)00007-7 Publication Type: Article ISSN: 0965-1748 Cited by:

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Footnotes:

1. The nucleotide sequence of KAT presented in this report had been deposited in the GenBank database (accession number AF395204).