Brain damage resulting from postnatal hypoxic-ischemic brain injury is reduced in C57BL/6J mice as compared to C57BL/6N mice
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- 作者：S. Wolfa ; N. Hainza ; A. Beckmanna ; C. Maackb ; MD Mengerc ; T. Tscherniga ; C. Meiera ; Carola.Meier@uks.eu" class="auth_mail" title="E-mail the corresponding author
- 关键词：8OHdG ; 8-hydroxydeoxyguanosin ; CC3 ; cleaved caspase-3 ; LFB ; Luxol Fast Blue ; Nnt ; nicotinamide nucleotide transhydrogenase ; NADPH ; nicotinamide adenine dinucleotide phosphate ; NO ; nitric oxide ; HI ; hypoxic-ischemic ; P ; postnatal day ; SSC ; saline sodium citrate ; ROS ; reactive oxygen species
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：1650
- 期：Complete
- 页码：224-231
- 全文大小：3090 K
文摘
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C57BL/6J and C57BL/6N sub-strains differ in their response to brain hypoxia-ischemia.
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Lesion size, microglia activation and apoptosis were reduced in C57BL/6J mice.
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In contrast, ROS-induced DNA damage was increased compared to C57BL/6N mice.
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Metabolic and genetic differences between strains might account for this diversity.