Novel nardosinane type sesquiterpenoids from Nardostachys chinensis Batal

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• 作者：Jin-Bo Zhang^a ; ^b ; Ming-Li Liu^a ; ^b ; Ying-Hui Duan^a ; ^b ; Hai-Yan Tian^a ; ^b ; Chang Li^c ; Yi Dai^a ; ^b ; ^{daiyi1004@163.com" class="auth_mail} ; Xin-Sheng Yao^a ; ^b ; ^c
• 关键词：Nardostachys chinensis ; Nardosinane sesquiterpenoids ; Absolute configuration
• 刊名：Tetrahedron
• 出版年：29 July 2014
• 年：2014
• 卷：70
• 期：30
• 页码：4507-4511
• 全文大小：589 K

文摘

Five new sesquiterpenoids Nardosinanone A–E (1–5), were isolated from the extract of Nardostachys chinensis, and their structures were determined by extensive spectroscopic analysis. Compound 1 featured a nardosinane sesquiterpenoid with an unusual tricyclic skeleton. Compounds 2–4 were new nardosinane sesquiterpenoids bearing a rare 10,11-epoxy group. The absolute configurations were determined by single-crystal X-ray diffraction analysis, ECD calculation method, the CD analysis of the in situ formed [Rh₂(OCOCF₃)₄] complex, and the CD data analysis based on the octane rule of cyclohexanone.