Cleavage and polyadenylation specific factor 4 targets NF-κB/cyclooxygenase-2 signaling to promote lung cancer growth and progression
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- 作者：Canhui Yia ; b ; 1 ; Yan Wangc ; 1 ; Changlin Zhangb ; 1 ; Yang Xuana ; Shilei Zhaoa ; Tianze Liub ; Wenbin Lib ; Yina Liaoa ; Xu Fenga ; Jiaojiao Haoa ; Yue Gaoa ; Wendan Yua ; Yiming Chena ; Chao Zhangd ; Wei Guoa ; wei1015@dmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Bing Tange ; tangbing@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Wuguo Dengb ; d ; dengwg@sysucc.org.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：CPSF4 ; COX-2 ; NF-κB ; Lung cancer
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：381
- 期：1
- 页码：1-13
- 全文大小：3959 K
文摘
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CPSF4 up-regulated the expression of COX-2 at mRNA and protein levels in lung cancer cells.
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CPSF4 increased the expression of p-IKKαβ and p-IκBα, the translocation of NF-κB from cytoplasm to nucleus, and the binding of p65 on COX-2 promoter.
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CPSF4 bound to COX-2 promoter directly, and thereby activated the transcription of COX-2.
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CPSF4 promoted lung tumor growth in a xenograft lung cancer mouse model by targeting COX-2 signaling.
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CPSF4 was positively correlated with COX-2 level in human lung cancer tissues. High expression of CPSF4 and COX-2 predicted poor prognosis of patients with lung cancers.