μMORE: A microfluidic magnetic oscillation reactor for accelerated parameter optimization in biocatalysis
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- 作者：Daniel Jussena ; jussendaniel@aol.com" class="auth_mail" title="E-mail the corresponding author ; Helmut Soltnerb ; h.soltner@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author ; Birgit Stutea ; b.stute@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author ; Wolfgang Wiecherta ; w.wiechert@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author ; Eric von Lieresa ; e.von.lieres@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author ; Martina Pohla ; ma.pohl@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Benzaldehyde (PubchemCID 240) ; Acetaldehyde (PubchemCID 177) ; 2-Hydroxy-1-phenylpropan-1-one (PubchemCID 101121)
- 刊名：Journal of Biotechnology
- 出版年：2016
- 出版时间：10 August 2016
- 年：2016
- 卷：231
- 期：Complete
- 页码：174-182
- 全文大小：1818 K
文摘
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Construction of a microfluidic device for biotransformations.
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Parallelized parameter optimization for biocatalytic processes at μscale.
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Magnetic bead-based enzyme immobilization, retention, and microfluidic mixing.
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His-tag immobilized thiamin diphosphate-dependent enzyme.
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Benzoylformate decarboxylase catalyzed formation of (R)-2-hydroxy-1-phenylpropan-1-one.