Effects of a Novel Fentanyl Derivative on Drug Discrimination and Learning in Rhesus Monkeys
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- 作者：Gerak ; Lisa R. ; Moerschbaecher ; Joseph M. ; Bagley ; Jerome R. ; Brockunier ; Linda L. ; France ; Charles P.
- 关键词：Mirfentanil ; Fentanyl derivative ; Discriminative stimulus effects ; Rhesus monkey
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：1999
- 出版时间：October, 1999
- 年：1999
- 卷：64
- 期：2
- 页码：367-371
- 全文大小：99.3 K
文摘
Three monkeys discriminated 1.78 mg/kg of mirfentanil while responding under a fixed-ratio 5 schedule of stimulus-shock termination. Two mirfentanil derivatives, OHM3295 and OHM10579, substituted for mirfentanil in all subjects. However, other drugs produced variable effects among monkeys; for example, μ and κ opioid agonists and clonidine substituted for mirfentanil on some occasions in two monkeys. Cocaine, amphetamine, and ketamine did not substitute in any subject. Opioid antagonists did not attenuate the effects of mirfentanil. In monkeys responding under a repeated acquisition and performance procedure, errors increased only during the acquisition phase at doses of mirfentanil that decreased response rates. Thus, unlike fentanyl, the discriminative stimulus effects of mirfentanil do not appear to be mediated exclusively through opioid receptors. Finally, mirfentanil does not appear to disrupt complex behavioral processes.