Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model
详细信息 查看全文
- 作者：Loqman A. Mohameda ; Jeffrey N. Kellerb ; Amal Kaddoumia ; kaddoumi@ulm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABCA1 ; ATP-binding cassette sub-family A ; member 1 ; APP ; amyloid precursor protein ; ACh ; acetylcholine ; AD ; Alzheimer's disease ; Aβ ; amyloid-β ; BBB ; blood&ndash ; brain barrier ; BSA ; bovine serum albumin ; ChEIs ; Cholinesterase inhibitors ; ELISA ; enzyme-linked immunosorbent assay ; FA ; formic acid ; GFAP ; glial fibrillary acidic protein ; GLT-1 ; Na ; + ; -dependent glutamate transporter ; IL1 ; interleukin-1 ; LRP1 ; low density lipoprotein receptor related protein 1 ; LTP ; long term potentiation ; P-
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1862
- 期：4
- 页码：778-787
- 全文大小：1645 K
文摘
- •
P-gp could play role in the development of AD by depleting Ach levels.
- •
Rivastigmine lowers Aβ brain load, at least in part, by upregulating P-gp and LRP1 at the BBB.
- •
P-gp deletion attenuates rivastigmine effect on Aβ and its related pathology.
- •
Rivastigmine's neuroprotective effect is P-gp expression dependent (APP/mdr1+/+ > APP/mdr1+/−>APP/mdr1−/−).