The double-edge role of B cells in mediating antitumor T-cell immunity: Pharmacological strategies for cancer immunotherapy
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- 作者：Jing-Zhang Wanga ; wangjingzhang1981@gmail.com" class="auth_mail" title="E-mail the corresponding author ; jingzhangwang@hebeu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yu-Hua Zhangb ; Xin-Hua Guoc ; Hong-Yan Zhanga ; Yuan Zhanga
- 关键词：DC ; dendritic cell ; NK ; natural killer cell ; BCR ; B-cell receptor ; TNF ; tumor necrosis factor ; MHC ; major histocompatibility complex ; LMP ; liver-metastatic pancreatic ; FcγR ; Fc gamma receptor ; TRAMP ; the transgenic adenocarcinoma of the mouse prostate model ; TGFβ ; transforming growth factor β ; TGFβR2 ; TGFβ receptor type 2 ; IL-10 ; interleukin-10 ; IL-10R1 ; the transmembrane receptor of IL-10 ; Tregs ; regulatory T cells ; Bregs ; regulatory B cells ; PD-1 ; programmed death-1 ; PD-L1 ; the programmed deat
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：36
- 期：Complete
- 页码：73-85
- 全文大小：794 K
文摘
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B cells play controversial roles, positively and negatively, in antitumor immunity.
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Studies supporting the dual role of B cells in antitumor immunity were summarized.
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Immunological properties of key B-cell subpopulations were described in detail.
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The mechanisms underlying the controversial effects of B cells were elucidated.
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B-cell-based pharmacological strategies were suggested for cancer immunotherapy.