Genetic variability in the system of natriuretic B peptide and principal toxicological parameters in workers exposed to lead

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• 作者：Marta Jurdziak^a ; Paweł Gać^a ; ^b ; ^{pawelgac@interia.pl} ; Rafał Poręba^a ; Marzena Gonerska^c ; Anna Jonkisz^c ; Małgorzata Gromek^c ; Małgorzata Poręba^c ; Anna Szymańska-Chabowska^a ; Grzegorz Mazur^a ; Małgorzata Sobieszczańska^c
• 关键词：Single-nucleotide polymorphism ; Natriuretic peptide B precursor ; Natriuretic peptide receptor C ; Blood lead concentration ; Blood zinc protoporphyrin concentration
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：Complete
• 页码：74-80
• 全文大小：474 K
• 卷排序：49

文摘

Genetic variability of NPPB and NPR3 in workers exposed to lead was studied. Relationships between polymorphisms rs632793, rs198388, rs198389 of NPPB gene and Pb-B, ZnPP were observed. Polymorphism rs6676300 of NPPB gene and rs1421811 of NPR3 gene exert no influence on Pb-B and ZnPP. The effect of genetic variability of NPPB and NPR3 on organ effects of exposure to Pb should be further subjected to scrutiny.