Helicobacter pylori seroprevalence in children with sleep-disordered breathing

详细信息    查看全文

• 作者：J. Wasilewska^a ; ^{jolanta.wasilewska@wp.eu" class="auth_mail" title="E-mail the corresponding author} ; M. Klukowski^a ; K. Debkowska^b ; J. Kilon^b ; D. Citko^c ; M. Flisiak^a ; M. Oleksinska^d ; M. Kaczmarski^a
• 关键词：Helicobacter pylori ; Seroprevalence ; Sleep disordered breathing ; Obstructing sleep apnea syndrome
• 刊名：International Journal of Pediatric Otorhinolaryngology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：87
• 期：Complete
• 页码：208-212
• 全文大小：390 K

文摘

Chronic Helicobacter pylori (HP) infection is considered to be a factor involved in obstructive sleep apnea syndrome (OSAS). This cross-sectional study examined the seroprevalence of HP in children with sleep-disordered breathing (SDB) in respect to OSAS severity and in reference to other common pediatric medical conditions.

Methods

Overnight polysomnography with pH-metry (PSG) was performed at a Sleep Laboratory (in the years 2008–2011). OSAS severity was determined based on Obstructive Apnea Index (OAI). Subjects were classified into primary snoring group (OAI < 1/hours), mild - moderate OSAS (OAI: 1–5/hour), and severe OSAS (OAI: ≥5/hour). HP IgG was tested by an enzyme-linked immunosorbent assay in the SDB (n = 115) and reference (n = 387) groups [reference group consisted of 4 subgroups based on ICD-10 diagnoses encompassing conditions affecting the skin, respiratory system, food hypersensitivity, and gastrointestinal tract]. Analyses were performed by nonparametric statistical tests.

Results

HP seropositivity was 10.4% (12/115) in the SDB group and 11.6% (45/387) in the reference group. HP positive and negative subjects did not differ in PSG, acid gastro-esophageal reflux index nor in age, sex, nutritional status (BMI-z score), and hematological indices in the SDB group. Seropositivity was found in 16.7% of the primary snoring group, 10.2% of mild-moderate OSAS, and in 11.1% of severe OSAS (chi² p = 0.832).

Conclusions

Children with SDB are not more predisposed to a chronic HP infection than children with other common chronic pediatric conditions. HP seropositivity does not influence OSAS severity but possible infection should none-the-less be considered on a case-by-case basis.