Histologic work-up of non-palpable breast lesions classified as probably benign at initial mammography and/or ultrasound (BI-RADS category 3)

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• 作者：R. Gruber^a ; S. Jaromi^a ; ^c ; M. Rudas^b ; G. Pfarl^c ; C.C. Riedl^a ; D. Flö ; ry^a ; O. Graf^a ; E.A. Sickles^d ; T.H. Helbich^a ; ^{thomas.helbich@meduniwien.ac.at}
• 关键词：Breast neoplasms ; Diagnosis ; Needle breast biopsy ; Cancer screening
• 刊名：European Journal of Radiology
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：82
• 期：3
• 页码：398-403
• 全文大小：514 K

文摘

Purpose

To determine the accuracy of a probably benign assessment of non-palpable breast lesions (BI-RADS category 3) at mammography and/or ultrasound with immediate histological work-up.

Materials and methods

Stereotactic or ultrasound guided core needle breast biopsy (NBB) was performed to evaluate 288 lesions, which were prospectively assessed as BI-RADS category 3. Imaging findings included 195 masses, 73 calcification cases, 16 focal asymmetries, and four architectural distortion cases. After NBB, patients underwent either open surgical biopsy (OSB) (n = 204) or mammographic follow-up (n = 84) for at least 24 months. Histological results of NBB were compared with those of OSB.

Results

Three of the 288 lesions (1.0 % ) proved to be malignant at histological work-up, two of them were ductal carcinoma in situ (DCIS) and one of them was an invasive carcinoma. NBB revealed invasive carcinoma in 1/288 (0.35 % ) and atypical ductal hyperplasia (ADH) in 13/288 (4.5 % ) lesions. OSB revealed DCIS in 2/204 (1 % ) and invasive carcinoma in 1/204 (0.5 % ) lesions. The two DCIS were underestimated as ADH by NBB. The remaining 285 (99 % ) lesions proved to be benign at OSB or remained stable during follow-up.

Conclusion

Confirmed by tissue diagnosis, the low likelihood of malignancy of prospectively assessed probably benign lesions is below the 2 % threshold established for BI-RADS category 3. Imaging follow-up is a safe and effective alternative to immediate histological work-up for such lesions.