Characterization and biocompatibility of injectable microspheres-loaded hydrogel for methotrexate delivery
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- 作者：Qifeng Danga ; Chengsheng Liua ; liucsouc@126.com" class="auth_mail" title="E-mail the corresponding author ; Yujie Wanga ; Jingquan Yanb ; Huiqin Wanc ; Bing Fand
- 关键词：Chitosan (PubChem CID ; 71853) ; α-Glycerophosphate (PubChem CID ; 14754) ; β-Glycerophosphate (PubChem CID ; 6101544) ; Lactic acid (PubChem CID ; 612) ; Giemsa stain (PubChem CID ; 13735) ; Hematoxylin (PubChem CID ; 442541) ; Eeosin (PubChem CID ; 11048) ; Methanol (PubChem CID ; 887) ; Sodium chloride (PubChem CID ; 5234)
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 January 2016
- 年：2016
- 卷：136
- 期：Complete
- 页码：516-526
- 全文大小：2437 K
文摘
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A new-typed microspheres-loaded hydrogel (CMs-CS-HG) was successfully prepared.
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CMs-CS-HG had good injectability and biocompatibility.
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CMs-CS-HG could be localized at administrating target after injection.
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MTX-loaded CMs-CS-HG exhibited long-term MTX release both in vitro and in vivo.