Reprogramming macrophage orientation by microRNA 146b targeting transcription factor IRF5

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• 作者：Liang Peng^a ; Hui Zhang^a ; Yuanyuan Hao^a ; Feihong Xu^a ; Jianjun Yang^a ; Ruihua Zhang^a ; Geming Lu^a ; Zihan Zheng^a ; Miao Cui^a ; Chen-Feng Qi^b ; Chun Chen^c ; Juan Wang^a ; Yuan Hu^a ; Di Wang^a ; Susan Pierce^b ; Liwu Li^c ; Huabao Xiong^a ; ^d ; ^{Huabao.Xiong@mssm.edu}
• 关键词：Interleukin 10 ; miR-146b ; Macrophage ; CRISPR/Cas9 ; Colitis
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：14
• 期：Complete
• 页码：83-96
• 全文大小：2445 K
• 卷排序：14

文摘

Interleukin 10-induced miR-146b plays a critical role in the regulation of macrophage polarization and colitis development by targeting IRF5. Treatment with miR-146b mimic significantly suppresses M1 macrophage activation and ameliorates colitis development.Interleukin 10 and Interleukin receptor are clearly involved in the development of inflammatory bowel diseases and other inflammatory diseases. Notably, the mutation of Interleukin 10 and Interleukin 10 receptor are clearly correlated with inflammatory bowel diseases. In the present study we show that Interleukin 10-induced miR-146b plays a critical role in the regulation of macrophage polarization and colitis development by targeting IRF5. Treatment with miR-146b mimic significantly suppresses M1 macrophage activation and ameliorates colitis development. The results highlight the potent role of miR146b in the control of immune responses and pathogenesis of inflammatory diseases.