Comparison of serum from gastric cancer patients and from healthy persons using FTIR spectroscopy
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- 作者：Daping Sheng ; Yican Wu ; Xin Wang ; Dake Huang ; Xianliang Chen ; Xingcun Liu
- 关键词：FTIR ; Fourier transform infrared ; IR ; infrared
- 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- 出版年：2013
- 出版时间：December, 2013
- 年：2013
- 卷：116
- 期：Complete
- 页码：365-369
- 全文大小：470 K
文摘
Since serum can reflect human beings¡¯ physiological and pathological conditions, FTIR spectroscopy was used to compare gastric cancer patients¡¯ serum with healthy persons¡¯ serum in this study. The H2959/H2931, H1646/H1550, H1314/H1243, H1453/H1400 and H1080/H1550 ratios were calculated, among these ratios, the H2959/H2931 ratio might be a standard for distinguishing gastric cancer patients from healthy persons. Then curve fitting was processed using Gaussian curves in the 1140-1000 cm?1 region, and the result showed that the RNA/DNA ratios of gastric cancer patients¡¯ serum were obviously lower than those of healthy persons¡¯ serum. The results suggest that FTIR spectroscopy may be a potentially useful tool for diagnosis of gastric cancer.