Editorial-The genetic association between asporin and osteoarthritis

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• 关键词：Hilbert's integral inequality ; Weight coefficient ; Hö ; lder's inequality
• 刊名：The Knee
• 出版年：2008
• 出版时间：June 2008
• 年：2008
• 卷：15
• 期：3
• 页码：vii-viii
• 全文大小：4436 K

文摘

Ten single nucleotide polymorphisms (SNPs) within the ASPN gene were genotyped in 775 affected siblings with radiographically confirmed hand and/or knee OA, and the allelic, genotypic and haplotypic association results were examined.

Results

One variant (SNP RS7033979) showed nominal evidence of association with both hand OA (P = 0.042) and knee OA (P = 0.032). Four additional SNPs showed nominal evidence of association with knee OA only. These associations were only observed with genotypic tests; the corresponding allelic and haplotype tests did not corroborate the single-point association results.

Conclusion

These data suggest that polymorphisms within ASPN are not a major influence in susceptibility to hand or knee OA in US Caucasians.