Hydroxy-safflor yellow A attenuates A尾1-42-induced inflammation by modulating the JAK2/STAT3/NF-魏B pathway
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- 作者：Zuo-hui Zhanga ; b ; Lin-jie Yua ; Xin-chen Huia ; c ; Zheng-zheng Wua ; Kai-lin Yina ; Hui Yanga ; d ; Yun Xua ; c ; d ; e ; xuyun20042001@aliyun.com" class="auth_mail
- 关键词：A尾 ; beta-amyloid ; AD ; Alzheimer&rsquo ; s disease ; GFAP ; glial fibrillary acidic protein ; HSYA ; hydroxy-safflor yellow A ; Iba-1 ; ionized calcium-binding adapter molecule 1 ; IKKs ; I魏B kinases ; IL ; interleukin ; iNOS ; inducible nitric oxide synthase ; JAK2 ; Janus Kinase 2 ; PFA ; paraformaldehyde ; STAT3 ; signal transducers and activators of transcription 3 ; TNF-伪 ; tumor necrosis factor-伪
- 刊名：Brain Research
- 出版年：14 May 2014
- 年：2014
- 卷：1563
- 期：Complete
- 页码：72-80
- 全文大小：3301 K
文摘
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HSYA ameliorated the memory deficits in A尾1–42-induced AD mice.
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HSYA suppressed inflammatory responses in A尾1–42-induced AD mice.
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The anti-inflammatory effect of HSYA was mediated by a novel JAK2-STAT3-NF-魏B pathway.