TGF-β and IL-21 cooperatively stimulate activated CD8+ T cells to differentiate into Tc17 cells
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- 作者：Hsin-Wei Chena ; b ; chenhw@nhri.org.tw" class="auth_mail" title="E-mail the corresponding author ; Jy-Ping Tsaia ; Tsung-You Yaoa ; Chia-Ling Hsieha ; I-Hua Chena ; Shin-Jen Liua ; b ; levent@nhri.org.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：IL-6 ; IL-21 ; Tc1 ; Tc17 ; T cell plasticity ; TGF-β
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：174
- 期：Complete
- 页码：23-27
- 全文大小：1012 K
文摘
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The combination of TGF-β plus IL-21 increases RORα, RORγt, and Batf mRNA levels.
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IL-21R is expressed on both naïve and activated CD8+ T cells.
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The combination of TGF-β plus IL-21, but not IL-6, converts Tc1 cells into Tc17 cells.