MiR-30a inhibits Th17 differentiation and demyelination of EAE mice by targeting the IL-21R
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- 作者：Xuebin Qua ; 1 ; Jun Zhoua ; 1 ; Ting Wanga ; 1 ; Jingjing Hanb ; Li Maa ; Hongli Yua ; Deqin Gengb ; Hongbin Fanb ; Qingshan Zhangc ; Fang Huab ; d ; Ruiqin Yaoa ; wenxi_yao@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MiR-30a ; Th17 ; Demyelination ; IL-21R
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：57
- 期：Complete
- 页码：193-199
- 全文大小：2391 K
文摘
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MiR-30a level is decreased during Th17 differentiation and process of MS and EAE.
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Enforced constitutive expression of miR-30a inhibits Th17 differentiation.
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In vivo miR-30a overexpression leads to fewer Th17 generation and alleviative EAE.
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IL-21R is a direct target of miR-30a.