Changes in body composition in heart failure patients after a resistance exercise program and branched chain amino acid supplementation

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• 作者：Juan Antonio Pineda-Juá ; rez^a ; Né ; stor Alonso Sá ; nchez-Ortiz^a ; Lilia Castillo-Martí ; nez^a ; Arturo Orea-Tejeda^a ; ^{oreatart@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Rocí ; o Cervantes-Gaytá ; n^b ; Candace Keirns-Davis^c ; ^{mieshe@comcast.net" class="auth_mail" title="E-mail the corresponding author} ; Carlos Pé ; rez-Ocampo^b ; Karla Quiroz-Bautista^b ; Mó ; nica Tenorio-Dupont^b ; Alberto Ronquillo-Martí ; nez^b
• 关键词：Resistance exercise ; Branched chain amino acids ; Heart failure
• 刊名：Clinical Nutrition
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：35
• 期：1
• 页码：41-47
• 全文大小：545 K

文摘

Heart Failure (HF) is a complex syndrome, which can include the physiological, neural hormonal and metabolic complications known as “Cardiac Cachexia” (CC). In the development of CC there is a release of catabolic cytokines (Tumor Necrosis Factor-α, interleukins 1 and 6) that cause a decrease of fat free mass and fat mass. These changes in body composition might be reversed with a therapeutic combination of resistance exercise and branched chain amino acid supplementation (BCAA).

Aim

Evaluate changes in body composition after a resistance exercise program and BCAA supplementation in patients with HF.

Methods

In a randomized clinical trial with 3 month of follow-up anthropometric body composition analysis and stress tests were evaluated at the beginning and in the end of the study. Patients were divided into two groups; the experimental group performed the resistance exercise program and received 10 g/day BCAA supplementation, and the control group only performed the resistance exercise program. Both groups were provided with individualized diets and conventional medical treatment.

Results

Changes were found in hip circumference between the groups (p = 0.02), and muscle strength was increased in the experimental group (8%) and the control group (11.4%) with no difference between them. METS and VO₂Max also increased in experimental and control groups (16.6% and 50.1% respectively). Regarding changes in symptoms, improvements in fatigue (45.4%), decubitus intolerance (21.8%) and dyspnea (25.4%) were observed in the overall sample.

Conclusion

Improvements in physical and functional capacities are attributed to resistance exercise program but not to the BCAA supplementation.

Clinical Trials Identifier: 2240511">NCT02240511.