Cyanidin-3-O-glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-α and exerts protective effects via Nrf2 pathway activation

详细信息    查看全文

• 作者：Daniela Ferrari^a ; ^{dani841984@libero.it} ; Antonio Speciale^a ; ^{specialea@unime.it} ; Mariateresa Cristani^a ; ^{mcristani@unime.it} ; Deborah Fratantonio^a ; ^{dfratantonio2@unl.edu} ; Maria Sofia Molonia^a ; ^{mmolonia@unime.it} ; Giulia Ranaldi^b ; ^{giulia.ranaldi@crea.gov.it} ; Antonella Saija^a ; ^{asaija@unime.it} ; Francesco Cimino^a ; ^{fcimino@unime.it}
• 关键词：Cyanidin 3-O-glucoside (PubChem CID ; 12303203) ; Wedelolactone (PubChem CID ; 5281813)
• 刊名：Toxicology Letters
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：264
• 期：Complete
• 页码：51-58
• 全文大小：954 K
• 卷排序：264

文摘

C3G prevents TNF-α-induced NF-kB pathway activation in Caco-2 cells. C3G improves Caco-2 intracellular redox status altered by TNF-α. C3G, also without any kind of stimulus, increases Nrf2 pathway activation. C3G possesses anti-inflammatory properties through the inhibition of NF-kB signalling. C3G beneficial effects appear to be due to its ability to activate cellular protective responses modulated by Nrf2.