In this manuscript we explore the role of IL-27 in sepsis-induced myocardial dysfunction.

The examine IL-27 levels in patients and show that the levels of this cytokine are higher in the non-SIMD group but also show that levels of IL-27 correlate with more severe APACHE II scores.

We then characterise mouse models of LPS induced sepsis and show that loss of IL-27 correlates with more pathology and with higher cytokine levels.

Anti-IL-27 treated mice increased the early level of cytokines compared with control IgG-treated mice. IL-27 treatment decreased the early levels of cytokines and myocardial injury biomarkers in wild-type (WT) mice.

We also show that the levels of IL-27 correlate inversely serum level of inflammatory cytokines and factors.