Precision assessment of heterogeneity of lymphedema phenotype, genotypes and risk prediction
详细信息 查看全文
- 作者：Mei R. Fua ; d ; mf67@nyu.edu" class="auth_mail" title="E-mail the corresponding author ; Yvette P. Conleyb ; Deborah Axelrodc ; d ; Amber A. Guthc ; d ; Gary Yua ; Jason Fletchera ; David Zagzage
- 关键词：Cancer ; Lymphedema ; Symptoms ; Phenotype ; Genotype ; Risk
- 刊名：The Breast
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：29
- 期：Complete
- 页码：231-240
- 全文大小：293 K
文摘
- •
Genetic variations may be one of the important factors that influence breast cancer survivors' responses to the inflammatory processes and vulnerability to lymphedema.
- •
IL1-ars17561 was marginally associated with symptom count phenotype of ≥8 symptoms.
- •
IL-4 rs2070874 was significantly associated with phenotype of impaired limb mobility and fluid accumulation.
- •
Phenotype of fluid accumulation was significantly associated with IL6 rs1800795, IL4 rs2243250 and IL4 rs2070874.
- •
Phenotype of discomfort was significantly associated with VEGF-C rs3775203 and IL13 rs1800925.